DDI PredictorQuantitative prediction of the impact on drug exposure of drug-drug interactions mediated by P450 cytochromes 3A4, 2D6, 2C9, 2C19 and 1A2, as well as genetic polymorphism of these cytochromes, the combined effect of drug interaction and cytochrome polymorphism, cirrhosis, and drug-drug interactions in cirrhotic patients.